Applications are open for this fully funded PhD studentship. This project will aim to define pathways mediating interstitial inflammation and fibrosis that are both common and different between three archetypal immune complex mediated glomerular diseases: IgAN, IgAV and LN, using pre-transfusion kidney transplant samples as healthy controls.
To achieve this, the doctoral candidate will use a combination of approaches. Formalin Fixed Paraffin Embedded tissue blocks of kidney tissue will be retrieved and sectioned on to glass slides. The ethical approval for this is already in place. Tissue sections will then be stained for infiltrating immune cells (including macrophages, mast cells, T-cells and B-cells) with immunofluorescent markers, and will then be subject to digital spatial transcriptomics using the GeoMx platform (which our laboratory has experience with and access to). This will allow infiltrating immune cells and the interstitium immediately surrounding them to be transcriptomically profiled with next generation sequencing.
Table of Content
Summary
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Benefits
The 3 year studentship offers
- Stipend at UKRI rates. for 2025/6 this will be £20,780 pa
Requirements
- Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject or overseas equivalent.
- This studentship is open to UK applicants only.
- To be classed as a UK/ home student, candidates must meet the following criteria:
- Be a UK or Irish national (meeting residency requirements), or
- Have EU settled status* or EU pre-settled status* (meeting residency requirement) or,
- Have indefinite leave to remain or enter
- *EU applicants who hold EU settled or EU pre-settled status please provide PGR Admissions with a share code (the one that starts with S) so we can verify your fee status. Please email to [email protected].
Application Documents
- CV
- Personal statement explaining your interest in the project, your experience and why we should consider you
- Degree Certificates and Transcripts of study already completed and if possible transcript to date of study currently being undertaken
- Evidence of English language proficiency if applicable
- In the reference section please enter the contact details of your two academic referees in the boxes provided or upload letters of reference if already available.
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Application Deadline
September 28, 2025How To Apply
Are you qualified and interested in this opportunity? Kindly go to
University of Leicester on le.ac.uk to apply
With your application, please include:
- CV
- Personal statement explaining your interest in the project, your experience and why we should consider you
- Degree Certificates and Transcripts of study already completed and if possible transcript to date of study currently being undertaken
- Evidence of English language proficiency if applicable
- In the reference section please enter the contact details of your two academic referees in the boxes provided or upload letters of reference if already available.
- In the funding section please specify CVS Barratt
- In the proposal section please provide the name of the supervisors and project title (a proposal is not required)
For more details, visit University of Leicester Scholarship webpage
